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Text File  |  1987-11-10  |  585b  |  14 lines
  1.          IN PATIENTS WITH RENAL IMPAIRMENT, CEFOTETAN DOSAGE SHOULD
  2.          BE CAREFULLY ADJUSTED TO AVOID TOXICITY (MAY ENHANCE RENAL
  3.          IMPAIRMENT).
  4.  
  5.          SOME CLINICIANS RECOMMEND THAT THE DOSAGE REGIMEN BE
  6.          ADJUSTED BASED ON THE PATIENT'S CREATININE CLEARANCE:
  7.  
  8.            CREATININE
  9.             CLEARANCE      DOSAGE INTERVAL        DOSAGE REDUCTION
  10.            (ML/MINUTE)         METHOD                  METHOD
  11.  
  12.              10-30           Q 24 hours            50% Q 12 hours
  13.               <10            Q 48 hours            25% Q 12 hours
  14.